Group sequential design for historical control trials using error spending functions

Control Proxy Functions for Sequential Design and Control Optimization

Optimal system design of “smart” products requires optimization of both the artifact and its controller. When the artifact and the controller designs are independent, the system solution is straightforward through sequential optimization. When the designs are coupled, combined simultaneous optimization can produce system-optimal results, but presents significant computational and organizational...

Group sequential designs for clinical trials.

neural classifier ensemble using error-correcting output codes: access control application

abstract biometric access control is an automatic system that intelligently provides the access of special actions to predefined individuals. it may use one or more unique features of humans, like fingerprint, iris, gesture, 2d and 3d face images. 2d face image is one of the important features with useful and reliable information for recognition of individuals and systems based on this ...

Estimation in adaptive group sequential trials

2 Group Sequential Designs (GSD) 2 2.1 GST object . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2.1.1 Alpha spending function (SF) . . . . . . . . . . . . . . . . 4 2.2 plan.GST example . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.3 Overall p-values for GSDs . . . . . . . . . . . . . . . . . . . . . . 6 2.3.1 Repeated p-values in a classical GSD . . . . . . . . . . . ...

Bayesian Decision Theoretic Design for Group Sequential Medical Trials having Multivariate Patient Response

In the conduct of sequential clinical trials primary statistical issues include design, monitoring and reporting. Here we focus on design issues. Group sequential designs have been developed to link patient accrual to when interim analysis should occur. In practice, trials with multiple arms and multivariate patient response are important. We present an approach for implementing and assessing o...